Colon was removed with nobody out in the second inning of the deciding Game 5 of the American League Division Series against the Yankees on Monday night because of an inflamed right shoulder. Colon was replaced by 22-year-old rookie right-hander Ervin Santana, who had not yet pitched in the series.
The team said Colon would be re-examined on Tuesday.
Colon's velocity was noticeably down from his first pitch, and after getting out of a first-and-third jam in the first inning by striking out Hideki Matsui, Colon hopped off the mound in obvious pain after throwing a pitch to Robinson Cano to lead off the second.
Colon was visited by manager Mike Scioscia and head athletic trainer Ned Bergert and talked them into staying in the game.
Colon threw two more pitches, but after the second pitch, he crouched on the mound, prompting Scioscia to summon Santana, who had been warming up.
Colon walked off the field gingerly and was given a rousing ovation by the sellout crowd in Angel Stadium. His final line was one-plus inning, two hits, no runs, one walk, one strikeout and 23 pitches, 15 of which were strikes.
Doug Miller is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.