He has pitched well against the Mariners in his career, with a 10-8 mark.
The Mariners will counter with southpaw Horacio Ramirez, whom they acquired from Atlanta in a trade this past offseason for reliever Rafael Soriano.
Saturday's game will be only the second official start of the year for Ramirez because of the weather problems earlier this month that forced the postponement of an entire series in Cleveland and one game in Boston.
Ramirez pitched well in his lone start, limiting Texas to one earned run in six innings while defeating the Rangers.
SEA: LHP Horacio Ramirez (1-0, 1.50 ERA)
Ramirez is 1-0 with a 2.25 ERA in his career against the Angels.
LAA: RHP Bartolo Colon (0-0, -. --)
Colon is 10-8 with a 4.32 ERA in his career against the Mariners.
Player to watch
Vladimir Guerrero is hitting .250 (2-for-8) against Ramirez in his career with two home runs.
On the Internet
Official game notes
710 AM KSPN, 830 AM KLAA (Español)
Sunday: Seattle (RHP Jeff Weaver, 0-2, 15.75) at Angels (RHP Ervin Santana, 1-2, 7.63), 12:35 p.m. PT
Monday: Detroit (LHP Mike Maroth, 2-0, 5.40) at Angels (RHP Jered Weaver, 0-1, 4.50), 7:05 p.m. PT
Tuesday: Detroit (RHP Jeremy Bonderman, 0-0, 2.25) at Angels (RHP John Lackey, 2-2, 2.55), 12:35 p.m. PT
Richie Brand is a contributor to MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.