Tyler Chatwood started in place of Santana and Garrett Richards will take the hill instead of Weaver.
"In talking to both Ervin and 'Weav,' they have thrown a lot of innings and have done extremely well this year," Scioscia said. "It comes to a point where we would be stretching them for diminishing returns right now.
"If we had 10 games left, you would see these guys out there, but they are really on fumes and need to just take a back seat."
Trailing Justin Verlander for the American League ERA crown by 0.01 at 2.41, Weaver said he is all right with not pitching.
"I'm not into the individual goals and numbers. It is a team game," Weaver said. "The only way I would have gone back out there is if I would have been on 19 wins going for 20."
The right-hander would have needed just four outs to surpass Verlander.
"Oops," Weaver joked. "Should have thrown a couple more zeros up there."
Santana, who racked up a career-high 228 2/3 innings, finishes with an 11-12 record and a 3.38 ERA to go with the no-hitter he threw at Cleveland on July 27. Weaver concludes the season with an 18-8 mark and a career-high 235 2/3 innings.
"This is the best I've felt at the end of the season in my career," Weaver said. "It is a pretty good thing. I was happy the way I have felt physically at the end of the year."