But Friday night didn't feel like just any Opening Day for the premier slugger. It was his first under the weight of a $240 million contract, his first without a Cardinals jersey on and his first in front of a West Coast fan base eager to see great things.
Afterward, Pujols maintained, it was no different.
"It was the same nerves I've been going through my first 11 years in the big leagues," he said after going 0-for-3 with a strikeout and an intentional walk in a 5-0 win over the Royals. "It's just something that my dad told me -- if you don't go through that, whether it's when you walk in early to the park and get ready, excited for the game, he always told me, 'You ain't ready.' I knew I was ready because I was going through that, and I wanted to do something special. But that's the way it goes. We got a win. I think that's the most important thing."
Three hours before game time, the parking lot was almost full. When gates opened at 5 p.m. PT, a sea of red flooded in. And when players were introduced, the noise was almost deafening.
In many ways, it was a typical Opening Day for the Angels.
In many ways -- because of the expectations and buzz surrounding the Pujols and C.J. Wilson signings -- it wasn't.
"For sure, this is the most exciting it's been in the area for the Angels," said Jared Pfeifer, a longtime Angels fan who resides in Yorba Linda, Calif. "I have never seen more people wearing Angels gear in one area my entire life."
The opening ceremonies included a David Cook national anthem, ceremonial first pitches thrown out by three members of the 2002 World Series team -- Tim Salmon, David Eckstein and Troy Percival -- and a C-17 flyover.
Before that, an announced crowd of 44,106 provided a loud ovation for Pujols, who doffed his cap from the third-base line in appreciation.
"They were excited," Pujols said. "They couldn't wait until this day. Neither could we. We were looking forward to it, and it was great to come up with the win today."
Angels fans have been jubilant about their club before.
There was that inspiring run to the 2002 World Series. There were the signings of Vladimir Guerrero and Don Baylor. The trades for Rod Carew and Nolan Ryan.
But this, perhaps, is different.
"This is definitely the most excited I've ever been going into a season," added Adam Rank of Huntington Beach, Calif. "There's just a lot of really high expectations."
Alden Gonzalez is a reporter for MLB.com. Read his columns and his blog, Gonzo and "The Show", and follow him on Twitter @Alden_Gonzalez. This story was not subject to the approval of Major League Baseball or its clubs.