Wells was hurt after stealing second base in the second inning, injuring his thumb while trying to catch himself after the popup slide.
"It didn't feel very good when it happened," said Wells, who stayed in the game, took his position in left field for the bottom half of the inning, then was removed in the middle of the third.
"Even if the tests say nothing significant as far as any procedures or anything, it's very sore, and it's going to take a little bit of time," said Angels manager Mike Scioscia. "Most likely he's going on the DL."
The injury couldn't have come at a worse time for Wells, who was batting .348 over his past six games and was showing signs of a potential turnaround.
"It's just part of the game," said Wells, batting .244 with six homers on the year. "I'll just take mental notes of where I was at this point. Whenever I get back, just pick up from there."
Langerhans, called up from Triple-A on Monday to take Hunter's place on the roster, banged his shoulder against the left-field wall while trying to track down a leadoff double by John Baker and was removed after being checked out. Langerhans said he has no idea how long he'll be out.
"This is the first time I've ever had anything like this," he added. "Hopefully I get better news tomorrow and go from there."
The injuries mean the Angels will have a starting outfield of Mike Trout in left, Peter Bourjos in center and Mark Trumbo in right, at least until Hunter returns. They don't have any more outfielders on the 40-man roster, so an array of moves are expected on Monday.
In Triple-A, the Angels have Kole Calhoun (.296 batting average, five homers), Drew Heid (promoted after Trout's callup), Doug Deeds (.253 with 13 RBIs) and Matt Long (.216 batting average).
Scioscia indicated the Angels will also make some moves on the pitching side, after their bullpen had to account for 6 2/3 innings on Sunday.