ANAHEIM -- Angels right fielder Vladimir Guerrero left after the fourth inning of Friday's game with the Mariners with irritation in his right knee and is listed as day-to-day.
Guerrero aggravated his knee in the first inning while running down a fly ball near the right-field foul line on a ball hit by Jose Lopez.
"When he broke for the ball down the line to make the catch to end the inning, his knee felt a little sore so we took him out as a precaution," Angels manager Mike Scioscia said. "It doesn't look like it's anything serious."
Guerrero made the first out of the fourth inning when he grounded out to shortstop but ran to first without any visible problems. The right fielder felt his knee stiffen while running.
"I think as the game went on it stiffened up a little bit," Scioscia said. "He was evaluated and doesn't look like it's anything other than irritation."
Guerrero isn't expected to play in either of the two remaining games on the homestand against the Mariners and will be evaluated again early next week.
Guerrero has been plagued by knee problems all season and has been the designated hitter 40 times this season to give his knees added rest.
Kendry Morales replaced Guerrero in right field and assumed his spot in the lineup as the third hitter.
Rhett Bollinger is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.