Pujols had been alternating between first base and DH over the past week, but manager Mike Scioscia kept him out of the field for the second consecutive game on Thursday.
"As much as we can keep him off his legs, I think it's important right now," said Sciocsia, using Kendrys Morales at first base against Mariners right-hander Hisashi Iwakuma.
Scioscia added that having Howie Kendrick and Mark Trumbo as possibilities at first base is a luxury.
"He is hanging in there," Scioscia said of Pujols, who suffered a right calf injury in August. "He's had some leg issues for the last month and I think there is some compensation that is involved when you try to play with one part that is injured. Your body is going to compensate in other ways. It can affect you."