Team USA announced Friday morning that Fuentes will not join the team due to an unspecified injury. He has been experiencing back stiffness, according to the Los Angeles Times.
Fuentes had been on the bereavement list, which caused him to miss the Classic's first round in Toronto.
The 33-year-old Fuentes signed with the Angels in the offseason after he had been with the Rockies from 2002-08. He broke in with the Mariners in '01.
Team USA will keep together its current roster.
Joe Frisaro is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.