Witherspoon, who just finished up a stint in the Arizona Fall League, put up a .268/.350/.418 line to go along with 34 steals in high A and Double-A this past season. The 23-year-old is listed by MLB.com as the seventh-best prospect in the Angels' system.
Brasier, 25, notched a 4.37 ERA and 13 saves in 59 2/3 innings for Triple-A Salt Lake, striking out 54 batters, walking 24 and posting a 1.51 WHIP.
The 27-year-old Sisk, acquired in the trade that sent Ervin Santana to the Royals, posted a 2.54 ERA in 67 1/3 innings for Triple-A Omaha in 2012, striking out 73, walking 32 and posting a 1.35 WHIP.
Below are some notables who are now exposed to the Rule 5 Draft and could be snatched up by another team -- though it's very likely that none of them are claimed:
Efren Navarro, a 26-year-old lefty-hitting first baseman who won a Minor League Gold Glove in 2011 and just posted a .294/.336/.403 line in Triple-A.
Matt Long, a 25-year-old lefty-hitting outfielder who posted a .282/.350/.462 line with 23 steals in Double-A and Triple-A.
Ryan Chaffee, 24, notched a 2.60 ERA and a 1.17 WHIP in 65 2/3 innings for high A and Double-A.
Jeremy Berg, 26, posted a 3.75 ERA in 74 1/3 innings at Double-A and Triple-A.
Catcher Carlos Ramirez, 24, who posted a .205/.312/.276 line in 85 Double-A games, then joined Witherspoon in the AFL.
Matt Shoemaker, who's 26 and went 11-10 with a 5.65 ERA in 29 Triple-A starts.
Any player who signs a Minor League deal before the Rule 5 Draft can also be taken, regardless of service time. For the Angels, that means outfielders J.B. Shuck and Trent Oeltjen, lefty starter Jo-Jo Reyes, right-handed starter Billy Buckner and lefty reliever Mitch Stetter, all signed earlier this month, can be snatched up by another team.
Any player taken in the Rule 5 Draft costs his new club $50,000. That player must then remain on the drafting team's active Major League roster for the entirety of the following season, or be offered back to the original club for $25,000.