San Diego pitcher Freddy Garcia, in camp trying to win a rotation job as a non-roster invitee, allowed three runs on three hits in three innings. He yielded two home runs and finished with three strikeouts.
After three Cactus League appearances, Garcia has a 13.50 ERA in 6 2/3 innings with 12 hits allowed.
"He got a couple of fastballs up and they took advantage," Padres manager Bud Black said of Garcia. "But the secondary pitches are going to be a good thing for Freddy. He's got to continue to work on the fastball. When he's down, he's good. When he's up, he's vulnerable."
Casey Kelly, who like Garcia is trying to win a rotation job, allowed two runs on four hits in three innings with one walk and one strikeout.
Kendrick, who entered the game hitting .533 with two home runs, hit a solo home run in the first inning off Garcia. Iannetta had a two-run homer and later walked with the bases loaded in the sixth inning to force in another run.
"How about that?" Angels manager Mike Scioscia said of Kendrick's third homer, lifting his Cactus League average to .566 (10-for-18). "He's just seeing the ball well right now. It doesn't take him long to get ready, I guess. He's ready to go."
Chase Headley and Nick Hundley had two hits apiece for the Padres, who also got a solo home run from Jesus Guzman off Wilson. For Guzman, it was his second home run of the spring. Will Venable hit a home run in the fifth inning and Alexi Amarista hit one out in the eighth.
Angels reliever Ernesto Frieri tossed a scoreless inning against his former team. He hasn't allowed a run in his first three outings this spring.
Witherspoon added to the final margin of victory with a three-run homer in the seventh inning and Lindsey matched with his own three-run blast in the ninth.
Up next: The Angels return home to Tempe on Friday to host the D-backs in a 12:05 p.m. PT game. Joe Blanton makes his second start of the Cactus League season, and should be joined by first baseman Albert Pujols, who is also playing his second game after spending two days working on running drills as he eases into his spring schedule following offseason right knee surgery.