"He's a good hitter," Danks said. "That's saying a lot when you stand out in that lineup. You have to just tip your hat. I didn't make two good pitches to him, but he did what good hitters are supposed to do and make me pay for it."
The Angels added a couple more runs that inning, on a double by the red-hot Howie Kendrick and a sacrifice fly by Josh Hamilton, starting his fifth straight game in right field.
The Angels (4-11-3) blew the game open in the fourth, scoring four runs on a double by Hank Conger, a groundout by Trout, a triple by Kendrick and a single by Albert Pujols.
Kendrick, who drove in two runs, and Pujols each went 2-for-3.
Pujols isn't slated to play first base for at least another week, but he started and ran for himself for a second straight day -- though he came out of the game upon reaching first base after his third plate appearance in the fourth. Pujols is 6-for-14 (a .429 batting average) this spring.
Vargas bounced back after giving up four runs in three innings against the Rockies his last time out, scattering a pair of hits, striking out five and finding success with his off-speed pitches.
"To be able to go out and have that secondary stuff work, and get swings and misses, it's always a good indication of them not being able to stay on your fastball," Vargas said. "For me, that's a good sign."
White Sox starter John Danks continued to struggle, giving up six runs on seven hits in 3 1/3 innings to put his Cactus League ERA at 11.74 over 7 2/3 innings.
Center fielder Blake Tekotte put the White Sox (8-7-2) on the board with an RBI triple in the third and right fielder Dewayne Wise hit a solo homer off Scott Downs to start the sixth.
J.B. Shuck added a two-run single in a four-run seventh inning for the Angels for a 12-2 lead.
Up next for the Angels: Tommy Hanson gets the start on Friday at 1:05 p.m. PT, as the Angels host the Mariners' split squad at Tempe Diablo Stadium. Hanson struggled with his fastball command last time out, giving up five runs on seven hits in a three-inning stint against the Royals. Josh Hamilton and Mark Trumbo have each started five straight games in the field and Albert Pujols is coming off playing in back-to-back games. All three of them may sit.