The Angels rallied from behind for an MLB-high 26th time, snapping a tie with the Yankees.
Mike Napoli homered and doubled, driving in three runs. Bobby Abreu drove in three runs, and Erick Aybar fell a homer shy of a cycle. Yankee-killer Howard Kendrick banged out three hits, driving in a pair of runs, and Gary Matthews Jr. had a pair of hits and two RBIs.
"We know Andy Pettitte, how he can handle a game," said Abreu, who played alongside the lefty for 2 1/2 seasons in the Bronx. "You know he's going to come right at you. You can be aggressive if that first pitch is where you want it, but if it's not, let it go and wait for your pitch.
"You have to be patient with Pettitte. That's what our guys did, and we were able to get him out of the game."
It was the fourth time on the homestand the Angels have overcome a deficit of four runs or more, a franchise record. It gave them back-to-back double-figure scoring efforts with Torii Hunter and Vladimir Guerrero on the disabled list with leg injuries.
Jered Weaver, the new ace, moved to 10-3, striking out nine in six innings while yielding four runs, three earned, on two walks and four hits. The Angels, through injuries and tragedy, have used 12 starting pitchers. Weaver, at 6-foot-7, has stood tall and resolute throughout.
"He's an All-Star, no doubt about it," said Angels manager Mike Scioscia, who is sending only his closer, Brian Fuentes, to St. Louis for the Midsummer Classic with Hunter forced to pull out with his adductor strain. "There are a couple of other All-Stars in that room."
Scioscia alluded to leadoff man Chone Figgins, Juan Rivera, Abreu and Napoli as Angels deserving of tickets to St. Louis.
"They grind," the Yankees' Johnny Damon said. "They keep competing, and their top two guys are just doing everything possible to disrupt us. It seems like Bobby is doing what Bobby does, and the other guys are just swinging great bats.
"They wear guys down like we do. They put all the pressure on you, and when you are out in the field, they are so fast and take the extra base."
Alex Rodriguez and Eric Hinske each homered twice for the Yankees, and Hideki Matsui also unloaded. Weaver served up a two-run homer to A-Rod, a solo homer to Hinske and an RBI single by Robinson Cano to spot the Yanks a 4-0 advantage going into the bottom of the fourth.
"Andy Pettitte's as tough as it gets when he gets a lead," Scioscia said. "These guys were swinging the bats well. Woody's home run definitely closed the gap and got us started. This guy's made a lot of progress."
The Angels got moving when Abreu singled home Aybar, who'd doubled to left leading off.
Everything came unglued for Pettitte in the fifth. After Kendrick -- a .469 career hitter against the Yankees -- singled, Wood, in his third start of the season, unleashed his first homer, to right-center.
"I got in a good count, 3-1, and he threw something -- a four-seamer, I think -- with a little fade on the outer part [of the plate]," Wood said. "I got extended. It felt good to get us going."
After singles by Robb Quinlan and Aybar, Abreu delivered his second RBI, a single to left, to end Pettitte's day.
Napoli greeted David Robertson with a two-run double to right-center. After a walk and steal by Gary Matthews Jr., Kendrick's second hit of the inning produced the final two runs.
"They have weapons," Yankees manager Joe Girardi said. "They keep the pressure on you, and if you give them free baserunners or make errors and walk people, they're going to hurt you and they're going to score runs. They don't need a lot of hits to score runs."
With his third hit in as many innings, Aybar tripled home Reggie Willits in the sixth against Robertson.
Napoli's 11th homer came against Brett Tomko in the seventh after Hinske's second homer of the day in the top of the inning against Darren Oliver, a two-run shot.
"Napoli, gosh, he's been killing us," Damon said. "It looks like he's found his groove and all those guys are stepping up with the two big guys gone."
Kendry Morales extended his hitting streak to a career-best 15 games with an RBI double in the eighth following Abreu's sacrifice fly against lefty Phil Coke. Matthews drove in a pair of runs with a single, his second hit.
A-Rod's second dinger, against Jason Bulger in the eighth, gave him sole possession of 10th place on the all-time list with 570. Matsui followed with a solo shot.
"He's so strong," Weaver said of A-Rod. "On the ball he hit against me in the first, it was on the inner part, not a bad pitch. It didn't sound like he got it all, but it carried."
The Angels, who go for a sweep on Sunday when John Lackey duels CC Sabathia, are 16-9 against the American League East and have won 16 of the past 21 against the Yankees at Angel Stadium.