Palmer, who has won seven of eight decisions, lasted five innings in his most recent start in Arizona against the Diamondbacks, yielding six earned runs on 10 hits and two walks.
True to form, the Angels gave Palmer a lot of support and won that game, 12-8. They have won nine of his 11 starts, averaging seven runs per game when Palmer takes the mound.
Right-hander Nick Blackburn will take the ball for the Twins.
"Barring something unforeseen, we'll start Matt Palmer," Scioscia said on Friday night. "It was Shane Loux or Matt."
Loux, who suffered a right shoulder inflammation pitching in relief after making his final start on May 10, is 2-2 with a 4.64 ERA in six starts. The Angels split those six games.
Sean O'Sullivan has taken most of the assignments in the No. 5 role of late, but the big right-hander was returned to Triple-A Salt Lake after going 5 1/3 innings in a win at Kansas City on Tuesday. O'Sullivan is 3-0 with a 3.72 ERA in his five starts, all victories by the Angels.
Palmer has been keeping busy in the bullpen with a 2.92 ERA in nine appearances. He's 7-1 with a 5.10 ERA in his 11 starts.
Palmer has been effective at home (4-1, 4.14) and against right-handed hitters, holding them to a .215 batting average and .363 slugging percentage. Left-handed batters are hitting .294 with a .412 slugging mark.
Palmer will be facing the Twins for the first time.
Lyle Spencer is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.