The Angels, hosts of the 2010 Major League All-Star Game on July 13 at Angel Stadium, will kick off the season at home against the Twins with a four-game series starting on April 5.
The Athletics will pay the Angels their first visit for three games to complete the opening homestand.
Among the highlights of the schedule will be the familiar Interleague series, home and away, with the Dodgers, along with trips to Wrigley Field in Chicago and St. Louis' Busch Stadium.
Along with the Dodgers, who will grace Angel Stadium from June 11-13, the Angels will welcome Interleague foes Milwaukee (June 15-17) and Colorado (June 25-27) for three games apiece.
The Angels welcome the Dodgers for three games on June 11-13 before invading Dodger Stadium for a three-game series on June 22-24.
The Halos will launch Interleague Play with a three-game series against the Cardinals in St. Louis on May 21-23. Their three games against the Cubs in the Windy City will be staged from June 18-20.
Los Angeles will make two trips to Boston and New York. The Yankees come to Angel Stadium for three games on April 23-25, with Boston venturing into Orange County for a three-game extravaganza on July 26-28.
A four-game series with the Red Sox will rock Fenway Park on May 3-6, with a second trip to Boston for a three-game series arriving Aug. 17-19.
American League West rival Texas won't make its first trip to Anaheim until the last week of June, playing three games from June 29-30 and July 1. The Rangers return at the end of the month for another three-game set, July 30-31 and Aug. 1.
The Rangers make their final visit of the season on Sept. 20-22. The Angels visit Texas on May 17-18 for two games, returning July 22-25 for four and wrapping up the season in Texas with four games, Sept. 30 through Oct. 3.
The Angels wrap up their home schedule with a three-game series against Oakland on Sept. 27-29.
Lyle Spencer is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.