Tsuyoshi Wada, a non-roster invitee who was released on Sunday, then re-signed to a Minor League contract the next day, started for the Cubs. The lefty walked Kole Calhoun to start the game and he reached third on Mike Trout's single before scoring on Albert Pujols' sacrifice fly.
Wada was facing the Angels' everyday lineup minus second baseman Howie Kendrick. Third baseman David Freese was scratched because of leg soreness prior to the game.
Wada had his longest outing of the spring, giving up two runs on four hits over four innings.
Mike Olt singled to lead off the Chicago second and reached third on Dan Vogelbach's single. One out later, Darwin Barney hit a game-tying RBI single and Eli Whiteside ended an 0-for-16 stretch with a single to load the bases. Starter Brandon Lyon was lifted, and Albert Almora reached on a fielder's choice, driving in Vogelbach for a 2-1 lead.
Lyon is one of the candidates for a spot in the Angels' bullpen, along with Fernando Salas, Michael Kohn and Nick Maronde.
Raul Ibanez tied the game with a leadoff homer in the Angels' fourth, his second of the spring. But Junior Lake gave the Cubs the lead with two outs in the fifth, connecting for a home run against Matt Shoemaker, continuing from where he left off on Sunday, when he launched three homers.
George Kottaras doubled with two outs in the seventh and scored on Zeke DeVoss' single for a 4-2 lead.
Olt, who is trying to make the Cubs' Opening Day roster, made a nice bare-handed grab of Trout's grounder and threw him out to open the third, and executed a backhanded grab in the fifth. Olt was slowed this spring by soreness in his right shoulder.
Almora, one of the Cubs' top prospects, had a scare in the fourth when he caught Collin Cowgill's fly ball, then slid hard into the wall. Almora lay on the track for a few minutes, but was able to get up and jog off the field. The Cubs said Almore has a bruised right knee, and that they expect him to be fine.
Up next for the Angels: The Angels wrap up Cactus League play in Phoenix on Wednesday, with No. 2 starter C.J. Wilson getting his sixth spring start against the A's at Phoenix Municipal Stadium. Wilson sports a 2.49 ERA in 21 2/3 innings this spring, walking eight batters and striking out 28. All of the everyday players will be taking part in a workout at Angel Stadium on Wednesday, in anticipation for the three-game, exhibition Freeway Series against the Dodgers, but Hank Conger will stay back to catch Wilson. Game time is 12:05 p.m. PT and can be seen on MLB.TV.