That will be followed by another home game on March 5 against the Rockies at the standard starting time of 12:05 p.m.
The Halos' first road game will be at Phoenix against the American League West rival Athletics on March 6. The A's will come to Tempe the following afternoon.
There will be one open date, on March 18, before Cactus League play wraps up on April 1 with a split-squad game at Tempe Diablo Stadium, with the Indians paying a visit. That night, in Anaheim, the Angels will play host to the Padres at 7:05 p.m.
An April 2 exhibition is set at Angel Stadium against the Dodgers, also at 7:05, before the spring concludes with an April 3 date at Dodger Stadium at 1:10 p.m.
The Dodgers and Angels also will face off twice in Arizona -- March 15 in Tempe and March 22 in Glendale, the Dodgers' home grounds.
The Halos will face Chone Figgins' new club, the Mariners, for the first time on March 21 in Tempe. The AL West rivals will meet again two days later in Peoria at the Mariners' home park.
The Rangers, runner-up to the Angels in the AL West in 2009, will welcome the Angels to Surprise on March 8. Texas added Darren Oliver this offseason, the Halos' bullpen workhorse the past three seasons.
The Rangers visit Tempe on March 25.
Figgins, the Angels' leadoff man and third baseman, signed with the Mariners as a free agent during the winter. The Angels will not face Boston, with John Lackey, or the Mets, with Kelvim Escobar, this spring.
The first day for pitchers and catchers to report to Angels' camp is Feb. 18.
The Halos open the regular season at Angel Stadium on April 5 against the Twins, with the first pitch set for 7:05 p.m.
Lyle Spencer is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.