But shortstop John McDonald -- who replaced All-Star Erick Aybar in the ninth -- kept his glove on Cano as the Mariners second baseman came to his feet. Cano came briefly off the base.
Angels manger Mike Scioscia challenged the call, which was overturned after a review.
The double would have given the Mariners a man on second with no outs in a 2-2 game. The next two batters both grounded out to second to end the 10th.
Mike Trout's 16th-inning double, the 100th of his career, was confirmed after Mariners manager Lloyd McClendon challenged because it appeared to the Mariners that Trout had missed first base, but the umpire's review showed he got the inside corner with a cleat and the call was confirmed.
Matthew DeFranks is an associate reporter for MLB.com. Follow him on Twitter @MDeFranks. This story was not subject to the approval of Major League Baseball or its clubs.