ANAHEIM -- Robinson Cano was called out at second base in the 10th inning after replay showed his foot coming off the bag while the tag was applied.
Cano led off the inning with a rope to right-center field and slid into second base ahead of Mike Trout's throw with what appeared to be a double.
Angels manger Mike Scioscia challenged the call, which was overturned after a review.
The double would have given the Mariners a man on second with no outs in a 2-2 game. The next two batters both grounded out to second to end the 10th.
Mike Trout's 16th-inning double, the 100th of his career, was confirmed after Mariners manager Lloyd McClendon challenged because it appeared to the Mariners that Trout had missed first base, but the umpire's review showed he got the inside corner with a cleat and the call was confirmed.